睡眠质量对慢性阻塞性肺疾病患者炎症水平的影响及与急
性加重的相关性分析
孙贝贝;任祥春;费广鹤
【期刊名称】《中华结核和呼吸杂志》 【年(卷),期】2018(041)005
【摘要】Objective To investigate the association of sleep quality with the levels of systemic inflammatory markers in patients with chronic obstructive pulmonary disease (COPD) and the correlations between the frequency of acute exacerbation of COPD (AECOPD) and Pittsburgh sleep quality index (PSQI).Methods A total of 198 COPD patients admitted in our hospital from October,2016 to June, 2017 were screened,and 124 patients were eligible for the study.On the first day of hospitalization, the serum samples and clinical data were collected, including white blood cells, lymphocytes, platelet count, CRP and PSQI.Poor sleep quality was defined as PSQI score >5.Results The percentage of COPD patients with poor sleep quality was about 68%.Poor sleep quality was positively correlated with the frequency of acute exacerbation in COPD patients.The ratio of neutrophil to lymphocyte (NLR), ratio of platelet to lymphocyte (PLR) and levels of CRP were higher in patients with poor sleep quality than those in the control group.NLR, PLR and CRP in peripheral blood of the patients with poor sleep quality were positively correlated with PSQI score.The CRP
睡眠质量对慢性阻塞性肺疾病患者炎症水平的影响及与急性加重的相
