Short-term Rosuvastatin Treatment for the Prevention of Contrast-induced Acute Kidney Inju

Short-term Rosuvastatin Treatment for the Prevention of Contrast-induced Acute Kidney Injury in Patients Receiving Moderate or High Volumes of Contrast Media: A Sub-analysis of the

TRACK-D Study

Jian Zhang;Yi Li;Gui-Zhou Tao;Yun-Dai Chen;Tao-Hong Hu;Xue-Bin Cao;Quan-Min Jing

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2015(128)006

【摘要】Background:Current randomized trials have demonstrated the effects of short-term rosuvastatin therapy in preventing contrast-induced acute kidney injury (CIAKI).However,the consistency of these effects on patients administered different volumes of contrast media is unknown.Methods:In the TRACK-D trial,2998 patients with type 2 diabetes and concomitant chronic kidney disease (CKD) who underwent coronary/peripheral arterial angiography with or without percutaneous intervention were randomized to short-term (2 days before and 3 days after

procedure)

rosuvastatin

therapy

or

standard-of-care.This

prespecified analysis compared the effects of rosuvastatin versus standard therapy in patients exposed to (moderate contrast volume [MCV],200-300 ml,n =712) or (high contrast volume [HCV],≥300 ml,n =220).The primary outcome was the incidence of CIAKI.The secondary outcome was a composite of death,dialysis/hemofiltration or worsened