Comparative research between Bai-hua Qian-hu, a Chinese traditional plant, and its active

Comparative research between Bai-hua Qian-hu, a Chinese traditional plant, and its active ingredient on nuclear factor-κB and tumor necrosisfactor-α in

isolated ischemia-reperfusion heart of rat

王弛;常天辉

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2004(117)003

【摘要】@@Ischemia-reperfusion (I/R) injury is a complicated pathophysiological process, which is involved in calcium overload, free radical production, metabolic abnormalities, and inflammatory reaction. With the development of modern molecular biology, the expression and regulation of gene in myocardial I/R injury are focused on NF-κB.1Inflammatory reactions play an important role in I/R injury.2 TNF-α, an important inflammatory cytokine, is regulated by NF-κB and counteracts the activation of NF-κB. Sometimes, improper activation of NF-κB can induce excessive inflammatory responses and injury, so, modulation of NF-κB activation may dedicate a new target in alleviation of myocardial I/R injury.3Our previous studies have proved that Bai-hua Qian-hu (Peucedanum praeruptorum Dunn, BQ), a Chinese traditional plant had cardioprotective action in I/R animals.4 Its active ingredient Pd-Ia, a Ca2+-influx blocker5 and K+-channel opener,6 had similar effects. Meanwhile, it relieved inflammatory reaction and apoptosis in

I/R myocardium through inhibition of interleukin-6 and Fas, bax, bcl-2 protein expression.7 However, the effects of BQ and Pd-Ia on the activation of NF-κB and the expression of TNF-α in I/R myocardium have not been clear yet. In this study, the effects of BQ and Pd-Ia on these two factors were investigated to further ascertain the molecular protective mechanism of BQ in I/R myocardium. 【总页数】3页(461-463)

【关键词】Peucedanum

praeruptorum

dunn;dl-praeruptorin

A;myocardium;ischemia;reperfusion;nuclear factor-κB;tumor necrosis facotr-α

【作者】王弛;常天辉

【作者单位】Department of Clinical Pharmacology,China Medical University,Shengyang

110001,China;Department

of

Clinical

Pharmacology,China Medical University,Shengyang 110001,China 【正文语种】中文 【中图分类】R3 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-medical-journal_thesis/0201254939891.html 【相关文献】

1.Comparative study of the effect of basic fibroblast growth factor and vascular endothelial growth factor on limb ischemia/reperfusion injury

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3.Effects of Lipoteichoic Acid induced Delayed Preconditioning on Ischemia-reperfusion Injury in Isolated Rat Hearts [J], 马世玉; 向继洲; 吴基良; 胡本容 4.Cardioprotection

by

polysaccharide

sulfate

against

ischemia/reperfusion injury in isolated rat hearts [J], Ying YANG; Shen-jiang HU; Liang LI; Guo-ping CHEN

5.Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway [J], Hong XIE; Jing ZHANG; Jiang ZHU; Li-xin LIU; Mario REBECCHI; Su-mei HU; Chen WANG

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