负载 rhBMP-2钙磷硅基活性骨修复材料的3D 打印构建
及生物学性能研究
李翠笛;陈芳萍;王金武;戴尅戎;刘昌胜
【期刊名称】《国际骨科学杂志》 【年(卷),期】2015(000)003
【摘要】Objective To fabricate recombinant human bone morphogenetic protein‐2 (rhBMP‐2) loaded mesoporous calcium silicate/calcium phosphate cements (MCS/CPC) scaffolds based on 3D bioplotting technique ,and investigate the combined effect of material component , mesoporous structure and growth factor on mechanical property ,cell adhesion potential and osteogenesis of the bone repair scaffolds .Methods Scaffolds with different designed structure were fabricated to study the effect of pore size and distribution on mechanical property and cell adhesion potential for optimal design . To obtain a hybrid system in the repair of bone defects , rhBMP‐2 was incorporated into the optimized scaffolds .The in vivo effects of CPC ,MCS/CPC and MCS/CPC/rhBMP‐2 scaffolds were further assessed in rat cranial defect models by histological analysis .Results MCS/CPC scaffolds with straight pore size of 350 μm possessed proper porosity (56 .6% ) , high mechanical strength (9 .8 MPa ) and good biocompatibility
.After
the
implantation
for
12
weeks ,MCS/CPC/rhBMP‐2 scaffolds resulted in much more bone
负载 rhBMP-2钙磷硅基活性骨修复材料的3D 打印构建及生物学性能研究
