Altered CD8+ T-cell counts as an early predictor of prognosis in critically ill immunocomp

Altered CD8+ T-cell counts as an early predictor of prognosis in critically ill immunocompromised patients with invasive pulmonary aspergillosis

Cui Na;Wang Hao;Long Yun;Liu Dawei

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2014(127)001

【摘要】Background The number of critically ill immunocompromised (CIIC) patients has increased dramatically in recent years,and they represent a high risk population for invasive pulmonary aspergillosis (IPA) infection.Host immunity should play a major role in determining the outcome and recovery of these patients.The purpose of this study was to evaluate the dynamic changes in host immune status and its potential influence on prognosis in CIIC patients with IPA.Methods We monitored the evolution of a number of key cellular and humoral parameters on days 1,3,and 10 (D1,D3 and D10) following ICU admission in sixty-two CIIC patients with microbiological evidence of IPA.We included immunoglobulins IgG,IgA and IgM,complement factors C3

and

C4,and

lymphocyte CD28+CD8+

T

subgroups cells,CD19+B

CD3+,CD4+,CD8+,CD28+CD4+,and

cells,and CD3-CD16+CD56+ natural killer cells (NK).Results The primary outcome was 28-day mortality.Thirty-eight (61.3％) patients died within the 28 days following ICU admission.Compared to patients who