糖原合成酶激醱3P基因多态性与重性II 抑郁障碍的相关性研
赵永萍;仇玉莹浏莹湊琴涨静;贾琼;程世翔??张蹇淳洁
［期刊名称］《中华行为医学与脑科学杂志》 【年(卷)，期】2015(024)004
【摘要】Objective To explore the association between glycogen synthase kinase-3。(GSK-30) rs334558 gene polymorphism and major depressive disorder (MDD) in Han Chinese.Methods Genotypes and alleles frequency of GSK-3& rs334558 polymorphism were examined in 250 patients and 300 healthy controls by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLPJ.SPSS 17.0 statistical so 代 ware was used for statistical analysis.Results ⑴ GSK-3。rs334558 locus of CC,CT+TT genotypes and alleles frequency distribution between patient group (CC’CT+TT genotypes:38.4%,61.6%.C,T alleles:63.2%,36.8%) and control group (CC,CT+TT genotypes:43.0%,57.0%.CJ alleles:67.2%,32.8%) had no significant difference (x2 =1.194,P=0.275.x2 =1.895 P=0.169);(2) There were significant differences of rs334558 genotypes and alleles between patient group (CC,CT+TT genotypes:37.9 % ,62.1 % .C,T alleles:63.5 % ,36.5 % ) and control group (CQCT+TT genotypes:51.0%,49.0%.C,T alleles:72.4%r27.6%) in female (x2=6.499,P =0.011.x2 =6.858;P=0.009).T allele was a risk factor for female MDD
糖原合成酶激酶3β基因多态性与重性抑郁障碍的相关性研究
