中国汉族人群5-羟色胺2C受体基因rs518147位点多态
性与强迫症的关联性
尹营营;张心华;王美建;刘世国
【期刊名称】《临床精神医学杂志》 【年(卷),期】2012(022)003
【摘要】Objective:To investigate the association between obsessive-compulsive disorder(OCD) and rs518147 polymorphism in the promoter of the serotonin 2C receptor gene(5-HTR2C) in Chinese Han population. Method: Direct sequencing technique was used to analyse the frequencies of rs518147 polymorphism of 5-HTR2C hemizygote (male) and genotype (female) in 308 patients(OCD: 123 male,185 female)diagnosed according to Chinese classification of mental disorders or international classification of diseases-10 criteria and 410 control (Control: 175 male, 235 female) and then a case-control association analysis was performed with SPSS13.0. ResultS:The study group were more likely to be G hemizygote (for male) and G + (GG and GC) genotype ( for female) than the control group ( male:χ 2 = 4. 973, P = 0. 026: female :χ 2 = 5. 243, P = 0. 022 ). The study group were more likely to take G allele (χ2 = 4.611, P = 0.032) than the control group. Conclusion: Our results indicated that the rs518147 polymorphisms 5-HTR2C may play a major role in the genetic predisposition to OCD in Chinese Han population.%目的:探讨中国汉族群体5-羟色胺2C受体基因(5-
中国汉族人群5-羟色胺2C受体基因rs518147位点多态性与强迫症的关联性
