陷窝蛋白-1与脑血管病
李红红;彭英
【期刊名称】《国际脑血管病杂志》 【年(卷),期】2014(022)001
【摘要】Caveolae are cholesterol-rich pits on the surface of cell membrane,and participate in various physiological processes.Caveolin-1 is an important membrane protein constituting caveolae.It exerts biological effects through binding a variety of signaling proteins.In the pathophysiological processes of cerebrovascular disease,caveolin-1 participates in maintaining the integrity of blood-brain barrier and stability of atherosclerotic plaques,and has regulating the release of inflammatory mediators and neuroprotection.This article reviews the associated advances in research on the correlation between caveolin-1 and cerebrovascular disease in order to provide a new idea for clinical therapy.%陷窝是细胞膜表面富含胆固醇的内陷微区,参与多种生理学过程.陷窝蛋白-1是参与构成陷窝的重要膜蛋白,通过与多种信号蛋白结合而发挥生物学效应.在脑血管病的病理生理学过程中,陷窝蛋白-1参与维持血脑屏障的完整性和动脉粥样硬化斑块的稳定性,而且具有调控炎性介质释放和神经保护作用.文章对陷窝蛋白-1与脑血管病关联性的研究进展进行了综述,旨在为临床治疗提供新的思路.
【总页数】4页(75-78)
【关键词】陷窝蛋白1;脑梗死;脑缺血;脑出血;血脑屏障
陷窝蛋白-1与脑血管病
