Regulation of cellular adhesion molecule expression in murine oocytes,peri-implantation an

Regulation of cellular adhesion molecule expression in murine oocytes,peri-implantation

and post-implantation embryos

佚名

【期刊名称】《细胞研究（英文版）》 【年(卷),期】2002(012)005

【摘要】Expression of the adhesion molecules, ICAM-1, VCAM-1, NCAM, CD44, CD49d (VLA-4, α chain),and CD11a (LFA-1, α chain) on mouse oocytes, and pre- and peri-implantation stage embryos was exam-ined by quantitative indirect immunofluorescence microscopy. ICAM-1 was most strongly expressed at theoocyte stage, gradually declining almost to undetectable levels by the expanded blastocyst stage. NCAM,also expressed maximally on the oocyte, declined to undetectable levels beyond the morula stage. On theother hand, CD44 declined from highest expression at the oocyte stage to show a second maximum at thecompacted 8-cell/morula. This molecule exhibited high expression around contact areas between trophecto-derm and zona pellucida during blastocyst hatching. CD49d was highly expressed in the oocyte, remainedsignificantly expressed throughout and after blastocyst hatching was expressed on the polar trophecto-derm. Like CD44, CD49d declined to undetectable levels at the blastocyst outgrowth stage. Expression ofboth VCAM-1 and CD11a was undetectable throughout.

The diametrical temporal expression pattern ofICAM-1 and NCAM compared to CD44 and CD49d suggest that dynamic changes in expression of adhesionmolecules may be important for interaction of the embryo with the maternal cellular environment as wellas for continuing development and survival of the early embryo. 【总页数】11页(373-383)

【关键词】CD11a/CD18, CD49d, CD44, CD54, CD56, CD106, Embryo 【作者】佚名

【作者单位】Department of Pathology, University of Sydney, NSW 2006 Australia;Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital,NSW 2065, Australia;Department of Pathology, University of Sydney, NSW 2006 Australia;Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital,NSW 2065, Australia;Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital,NSW 2065, Australia;Department of Pathology, University of Sydney, NSW 2006 Australia

【正文语种】中文 【中图分类】Q2 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_cell-research-

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