非小细胞肺癌表皮生长因子受体基因突变274例分析
王艳;吴如梦;夏晓冰;杜秀平;姬怀雪
【期刊名称】《中国药房》 【年(卷),期】2024(029)020
【摘要】OBJECTIVE:To study the gene mutation status of epidermal growth
factor
receptor(EGFR)in
non-small
cell
lung
cancer(NSCLC)patients and its relationship with clinical indexes,and to provide reference for individualized administration of EGFR-TKI in NSCLC patients. METHODS:Totally of 274 NSCLC patients from the northern of Jiangsu area were selected from our hospital during Jan. 2015-Dec. 2017. Mutation status of EGFR gene in lung tissue was determined by amplification refractory mutation system (ARMS)-TaqMan PCR assay. The relationship of EGFR gene mutation with clinical indexes as gender,age, smoking status, staging, tumor differentiation and pathological type were analyzed retrospectively. Compared with related literatures,the regional differences of EGFR gene mutation were analyzed. RESULTS:Among 274 NSCLC patients,112 patients suffered from EGFR gene mutation with total mutation rate of 40.88%. There were 50,57,3,2 cases of exon 19,exon 21,exon 20 and exon 19+21 mutation,and the types of EGFR gene mutation were delE746-A750,L858R and insH773-V774H,etc. The mutation rates of EGFR gene exon
19,exon
21
in
non-smoking,early,well-differentiated
and
非小细胞肺癌表皮生长因子受体基因突变274例分析
