瑞苏伐他汀和阿托伐他汀治疗对冠心病患者妊娠相关血清
蛋白A的影响
王政;杨树森;陈红丽;李为民;周宏艳
【期刊名称】《中华老年心脑血管病杂志》 【年(卷),期】2009(011)008
【摘要】Objective To observe the effect of rosuvastatin and atorvastatin therapy on pregnancy-associated plasma protein-A(PAPP-A) in the patients with coronary heart disease(CHD). Meth-otis 117 patients with CHD verified by invasive coronary angiography were selected. Of them,46 had acute coronary syndrome(ACS,including non-ST-elevation myocardial infarction and unstable angina) and 71 had stable angina, They were randomly assigned to rosuvastatin(60 patients) and atorvastatin(57 patients) groups. PAPP-A, hs-CRP and lipids were measured before and after 1 and 6 months therapy. Results PAPP-A and hs-CRP were significantly increased in 46 patients with ACS compared with 71 patients with stable CHD (P<0.05). After 1 and 6 months therapy with rosuvastatin the level of PAPP-A was significantly decreased compared with baseline. Al-though the level of PAPP-A in atorvastatin group did not show difference at 1 month,it was sig-nificantly decreased at 6 months. Although the level of hs-CRP in both rosuvastatin and atorvasta-tin groups did not show difference at 1 month compared with baseline, it was significantly de-creased at 6
瑞苏伐他汀和阿托伐他汀治疗对冠心病患者妊娠相关血清蛋白A的影响
