糖尿病足患者血清 Lp(a)和 CysC 水平及其与中医证型
的关系
赵静静;王伟灵;邢嘉翌;张莹;杨沁彤;赵延荣
【期刊名称】《山东医药》 【年(卷),期】2015(000)020
【摘要】目的:检测糖尿病足(DF)患者血清脂蛋白(a)[Lp(a)]和半胱氨酸蛋白酶抑制剂C(Cys C)水平,分析两指标与DF湿热毒盛证和脾肾阳虚、经脉不通证两种证型的关系。方法选择DF湿热毒盛证患者139例( A组),DF脾肾阳虚、经脉不通证患者46例(B组)和单纯T2DM患者78例(C组)。采集空腹静脉血,测定各组血清Lp(a)、Cys C,并对结果进行分析。结果各组血清Lp(a)、Cys C水平比较,A、B组高于C组,B组高于A组,P<0.05或<0.01。单因素Logistic回归分析显示,Lp(a)和Cys C是DF脾肾阳虚、经脉不通证的危险因素(P均<0.05);多因素Logistic回归分析显示,Lp(a)为DF脾肾阳虚、经脉不通证的独立危险因素(P<0.05)。结论 DF患者血清Lp(a)和Cys C水平显著升高,Lp( a)和Cys C可能参与了DF脾肾阳虚、经脉不通证患者大血管病变的发生、发展。%Objective To detect the levels of lipoprotein ( a) [ Lp( a) ] and cysteine proteinase inhibitor C ( Cys C) in serum of patients with diabetic foot (DF), and to analyze the correlations of two indicators with dampness-heat type, yang deficiency of spleen and kidney combined with meridian barrier type .Methods A total of 139 patients with damp-ness-heat type ( group A ) , 46 patients with yang deficiency of spleen and kidney combined