调节性T 细胞及其在抗肿瘤免疫疗法中的临床应用 - 图文

154Author name et al. / Engineering 2(2016) xxx–xxx8. 结论FOXP3+调节性T细胞是哺乳动物免疫系统的重要组成部分，对维持免疫稳态而言至关重要。越来越多的数据表明在肿瘤微环境中，FOXP3+调节性T细胞是免疫系统的有效抑制因子。近年来，靶向调节性T细胞的肿瘤免疫疗法已取得有效的临床效果。然而，要使用抗肿瘤免疫疗法治愈大多数人类癌症患者仍有很长的路要走。例如，有一种策略声称可特异性消耗肿瘤中的调节性T细胞并且不会产生有害副作用，但这种策略是否有效仍有待确定。对于炎症驱动的肿瘤进展，肿瘤组织浸润调节性T细胞及其功能塑性与不稳定性仍需进一步研究。为了加深我们对肿瘤组织浸润调节性T细胞的理解，有必要开展更详细的功能研究。目前用于探索肿瘤微环境中活细胞状态的新方法（如单细胞测序）正在发展中。这些新方法的使用将极大地提高我们对于肿瘤的了解并有助于开发新的肿瘤疗法。Compliance with ethics guidelineFeng Xie, Rui Liang, Dan Li, and Bin Li declare that they have no con?ict of interest or ?nancial con?icts to dis-close.References [1] Prise KM, O’Sullivan JM. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer 2009;9(5):351–60. [2] Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363(8):711–23. [3] Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. 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