Oligomerization of Vibrio cholerae Hemolysin Induces CXCR3 Upregulation and Activation of B-1a Cell

Oligomerization of Vibrio cholerae Hemolysin Induces CXCR3 Upregulation and Activation of B-1a Cell

Gayatri Mukherjee;Kalyan K Banerjee;Tapas Biswas

【期刊名称】《中国免疫学杂志（英文版）》 【年(卷),期】2008(005)003

【摘要】The hemolysin oligomer promotes the proliferation of B-1a cells and the expression of CD25, which is indicative of cell activation, on B-1a cells. The upregulation of CD86 induced by the oligomer showed its selective bias for the B7-2 member of B7 family while the monomer failed to induce these effects. The oligomer induced the expression of CXCR3, associated with B cell activation, while the monomer induced the expression of CXCL4, a powerful angiostatic chemokine. In conclusion, we found that B-1a cells responded to the apoptogenic monomer by expressing CXCL4, whereas oligomerization of the immunogen induced CXCR3 to shift the response towards activation. Cellular & Molecular Immunology. 2008;5(3):231-234. 【总页数】4页(231-234)

【关键词】B-la cell, CD86, CXCL4, CXCR3, Vibrio cholerae hemolysin 【作者】Gayatri Mukherjee;Kalyan K Banerjee;Tapas Biswas

【作者单位】Divisions of Immunology, National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM, Kolkata-700 010, West