肿瘤坏死因子-α-238基因多态性与结核病易感性关系的荟
萃分析
张芝娇;朱航;蒲昫頔;张帆;雷迅;周文洁;汪洋
【期刊名称】《中华结核和呼吸杂志》 【年(卷),期】2013(036)001
【摘要】Objective A comprehensive meta-analysis was performed to investigate the relationship between TNF-238G/A polymorphism and tuberculosis
susceptibility.Methods
Tuberculosis,TB,mycobacteria,polymorphism,variant,mutation,susceptibility,tumor necrosis factoror,TNF,cytokine,and gene were used as key words both in Chinese and English to search all the published related articles in Pubmed,Embase,Web of science,Science Direct,Springer Link,EBSCO,Wanfang and Chinese Journal Full-text Database until October
2011.HWE
test
was
performed studies
was
in
all
the
comparisons.Heterogeneity across determined,and
sensitivity analyses were conducted.Results Nine case-control studies were included.The meta-analysis indicated that there was no significant association between TNF-238G/A polymorphism and tuberculosis susceptibility (GA + AA vs GG model:OR =1.00,95％ CI:O.77-1.32 ; A vs G model:OR =1.00,95％ CI:0.77-1.30).No significant heterogeneity (Q was 5.04 and 5.82 respectively,P ＞ 0.05) and publication bias (GA + AA vs GG model:Begg test Z =0.73,Egger test t =1.94,P ＞ 0.05 ; A vs G
model:Begg test Z =0.52,Egger test t =1.72,P ＞ 0.05) were demonstrated.Sensitivity analyses further indicated the reliability of the study (OR were O.94-1.10 respectively,all P ＞0.05).Conclusion Our study did not detect any association between TNF-238G/A polymorphism and tuberculosis susceptibility.%目的 综合评价肿瘤坏死因子(TNF)-α-238基因多态性与结核易感性的关系.方法 以tuberculosis、TB、mycobacteria、polymorphism、variant、mutation、susceptibility、tumor necrosis factoror、TNF、cytokine和gene为检索词,检索Pubmed、Embase、Web of science、ScienceDirect、SpringerLink和EBSCO数据库.以结核、肿瘤坏死因子、基因、多态性、细胞因子、易感性、敏感性、相关性、关联性为中文检索词,检索万方数据、中国知网中文数据库.所有数据库检索时间截止2011年10月底.检验各组Hardy-Weinberg遗传平衡定律,评估各研究结果的异质性及发表偏倚.结果 本研究共纳入9篇病例对照研究,荟萃分析结果表明,TNF-α-238基因型(GA+ AA/GG和A/G)在各组的分布差异均无统计学意义(OR值均为1.00,95％ CI为0.77 ～ 1.32).未见显著异质性(Q值分别为5.04和5.82,均P＞0.05).无发表偏倚(Begg检验,Z值分别为0.73和0.52；Egger检验,t值分别为1.94和1.72,均P＞0.05).敏感度分析结果表明,本研究结果的稳定性较好(OR值为0.94 ～ 1.10,均P＞0.05).结论 TNF-α-238基因多态性与结核病易感性无显著关联性.
【总页数】5页(33-37)
【关键词】结核;肿瘤坏死因子-α;多态性,单核苷酸;疾病易感性;Meta分析 【作者】张芝娇;朱航;蒲昫頔;张帆;雷迅;周文洁;汪洋
【作者单位】400016 重庆医科大学公共卫生与管理学院 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-tuberculosis-respiratory-diseases_thesis/0201232335170.html 【相关文献】
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肿瘤坏死因子-α-238基因多态性与结核病易感性关系的荟萃分析
