Renal Protective Activity of Hsian-tsao Extracts in
Diabetic Rats
MIN YANG;ZHENG-PING XU;CAI-JU XU;JIA MENG;GANG-QIANG DING;XIAO-MING ZHANG;YAN WENG
【期刊名称】《生物医学与环境科学（英文版）》 【年(卷),期】2008(021)003
【摘要】Objective To investigate the renal protective activity of Hsian-tsao Mesona procumbens Hemsl. water extracts in diabetic rats. Methods Thirty Sprague-dawley female rats were randomly divided into three groups (n=10 each), \group\with intraperitoneal saline injection, \injection per kg of body weight and \administration of Hsian-tsao extraction everyday for 4 weeks after intraperitoneal streptozotocin injection. The body weight and blood sugar were measured before and after model induction in the three groups. Thrombospondin-1 (TSP-1) expressions in the kidney were monitored by immunohistochemistry. Kidney ultrastructural changes were also analyzed by using transmission electron microscopy. Results Before diabetic model induction, there were no significant differences among the three groups in body weight and blood sugar. Four weeks after the induction of diabetes, the differences became statistically significant. Electron microscopy also revealed disruption of the foot
processes of the podocytes and other damages in diabetic group. These damages were significantly less severe in Hsian-tsao group when compared with the diabetic group. TSP-1 expressions in the kidney were significantly increased in both the diabetic group and Hsian-tsao group, but it was relatively lower in Hsian-tsao group than in diabetic group. Conclusion Our results showed that Hsian-tsao treatment in the diabetic rats effectively prevented the pathological alterations in the kidney and decreased the TSP-1 expression. It was suggested that Hsian-tsao had protective effect on the kidneys of the diabetic rats. 【总页数】6页(222-227)
【关键词】Rat; Mesona procumbens Hemal.; Diabetic nephropathy; Thrombospondin-1
【作者】MIN YANG;ZHENG-PING XU;CAI-JU XU;JIA MENG;GANG-QIANG DING;XIAO-MING ZHANG;YAN WENG
【作者单位】Zhejiang University, School of Medicine, Hangzhou 310058, Zhejiang, China;Zhefiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, Zhejiang, China;Zhefiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, Zhejiang, China;Zhefiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, Zhejiang, China;Zhefiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, Zhejiang, China;Zhejiang University, School of Medicine, Hangzhou 310058,
Zhejiang, China;Zhejiang University, School of Medicine, Hangzhou 310058, Zhejiang, China 【正文语种】中文 【中图分类】R31 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_biomedical-environmental-sciences_thesis/0201222128074.html 【相关文献】
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Renal Protective Activity of Hsian-tsao Extracts in Diabetic Rats
