结肠癌组织中TRIM2蛋白的表达及临床意义

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王娟;季刚

【期刊名称】《国际外科学杂志》【年(卷),期】2018(045)008

【摘要】Objective To study the expression of TRIM2 protein in colon cancer tissues and paracancerous tissues and its relationship between TRIM2 protein expression and clinicopathological parameters and prognosis of patients with colon cancer.Methods Immunohistochemistry was used to detect the expression of TRIM2 protein in colon cancer tissues and paracancerous tissues of 200 colon cancer patients undergoing colon cancer radical surgery from Januany to December 2013 in the First Affiliated Hospital of Air Force Military Medical University.According to the results of TRIM2 protein expression,patients were divided into TRIM2 low expression group (n =114) and TRIM2 high expression group (n =86).The relationship between TRIM2 protein expression and clinicopathological parameters and prognosis in patients with colon cancer were analyzed by chi-square test,Kaplan-Meier method and log-rank test.Results There were 57％ (114/200) patients with low expression of TRIM2 protein in 200 cases of colon cancer,and there was a statistically significant difference compared with the adjacent tissues (P ＜ 0.001).The expression of TRIM2 protein was associated with tumor invasion depth (P =0.010),lymph node metastasis

(P =0.019),UICC clinical stage (P ＜ 0.001) and vascular tumor embolus (P =0.025).The 5-year overall survival and disease-free survival of patients with high TRIM2 expression were better than those with low TRIM2

expression

[(55.64

0.98)

months,x2

=20.982,P

＜

0.001].Univariate analysis suggested that UICC clinical staging (P =0.013),depth of tumor invasion (P =0.002),and TRIM2 protein expression (P ＜ 0.001) were risk factors for 5-year overall survival and tumor-free survival after radical resection of colon cancer.Multivariate analysis showed that TRIM2 protein expression was an independent risk factor for 5-year overall survival and disease-free survival in patients with colon cancer (HR =0.346,95％ CI:0.204 ～ 0.588,P ＜ 0.001;HR =0.330,95％ CI:0.195-0.560,P ＜0.001).Conclusion The expression of TRIM2 protein in colon cancer tissues is decreased and associated with tumor progression and poor prognosis.It can be used as a molecular marker for prognosis of postoperative colon cancer patients.%目的研究结肠癌组织和癌旁组织中TRIM2蛋白的表达及其与结肠癌患者临床病理参数和预后的关系.方法采用免疫组织化学法检测2013年1-12月空军军医大学第一附属医院行结肠癌根治术的200例结肠癌患者结肠癌组织及癌旁组织中TRIM2蛋白的表达,根据蛋白表达结果分为TRIM2低表达组(n=114)及TRIM2高表达组(n=86),利用x2检验、Kaplan-Meier法和Log-rank检验分析TRIM2蛋白表达与结肠癌患者临床病理参数及预后的关系.结果在200例结肠癌患者癌组织中57％ (114/200)患者TRIM2蛋白低表达,与癌旁组织相比差异具有统计学

意义(P＜0.001).TRIM2蛋白的表达与肿瘤浸润深度(P =0.010)、淋巴结转移(P=0.019)、UICC临床分期(P ＜0.001)及脉管癌栓(P =0.025)相关.TRIM2高表达组患者5年总体生存率及无瘤生存率均优于TRIM2表达低组患者[(55.64±0.98)个月,x2=20.982,P＜0.001].单因素分析结果提示UICC临床分期(P=0.013)、肿瘤浸润深度(P =0.002)、TRIM2蛋白表达(P＜0.001)是影响结肠癌根治术后5年总体生存率和无瘤生存率的危险因素.多因素分析显示TRIM2蛋白表达是影响结肠癌患者术后5年总体生存率和无瘤生存率的独立危险因素(HR=0.346,95％ CI:0.204～0.588,P＜0.001;HR=0.330,95％CI:0.195～0.560,P＜0.001).结论 TRIM2蛋白在结肠癌组织中表达降低并与肿瘤进展和不良预后相关,可作为结肠癌术后患者生存预后的分子标记物. 【总页数】7页(533-538,封4)

【关键词】结肠肿瘤;免疫组织化学;预后;TRIM2 【作者】王娟;季刚

【作者单位】710032 西安,空军军医大学第一附属医院消化外科;710032 西安,空军军医大学第一附属医院消化外科【正文语种】中文【中图分类】【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_international-journal-surgery_thesis/0201233142207.html 【相关文献】

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