超声斑点追踪技术评价2型糖尿病伴高血压病心脏局部收
缩功能的研究
赵策瑶,龙 莎,吴燕华,端学军,黄毅斌(深圳市中医院超声科,广东 深圳 518000)
【摘 要】Abstract:Objective To evaluate the effects of type 2 diabetes mellitus(DM)on left ventricular regional systolic function in hypertensive patients by speckle tracking echocardiography.Methods Speckle tracking
echocardiography
was
performed
on
hypertensive
patients(n=57),including 28 patients complicated with type 2 diabetes mellitus,healthy subjects(n=30)at apical long axis,two-chamber and four-chamber views.The peak systolic longitudinal strain was measured in the apical views.Results Compared with the healthy subjects,LAD and LVD in hypertensive patients complicated with type 2 diabetes mellitus was larger,SBP and DBP was higher,the difference was significant(P<0.05);the difference of IVS and LVPW and LVMI in the hypertensive patients complicated with type 2 diabetes mellitus was significant(P<0.05),compared with the other two groups;the ejection fraction had no difference in the three groups.Compared with the healthy subjects,the peak systolic longitudinal strain decreased in the hypertensive patients,while in the complicated with type 2 diabetes mellitus the difference was more significant(P<0.05).Conclusion By speckle tracking echocardiography we can found:the regional systolic function of the
left ventricle decreased in hypertensive patients which the ejection fraction was normal,and the reduction was more significant in the hypertensive patients complicated with type 2 diabetes mellitus,which indicated that type 2 diabetes mellitus could promote the impairment of the cardiac function in hypertensive patients. 【期刊名称】现代诊断与治疗 【年(卷),期】2018(029)014 【总页数】3
【关键词】Keywords:Echocardiography;Speckle Tracking;Diabetes Mellitus;Hypertension,Ventricular Function;Left
2型糖尿病患者无心血管症状,则其常规二维超声心动图所测的反映左室收缩功能的指标左室射血分数(EF)通常是正常的。然而有研究表明,2型糖尿病患者存在心内膜下心肌缺血[1]。而心内膜下心肌参与了心室收缩功能的完成,因而2型糖尿病对左心室的收缩功能会产生影响。近年发展起来的超声斑点追踪技术能准确地反映心肌的运动和评价心肌长轴方向上的运动[2]。本文旨在利用超声斑点追踪技术来探讨合并2型糖尿病的高血压病患者与单纯性高血压病患者左心室收缩功能的差异,从而来评估2型糖尿病对高血压病患者左室局部收缩功能的影响。报道如下。
1 资料与方法
1.1 一般资料 选取我院2016年10月~2017年2月确诊的高血压病患者57例,其中合并2型糖尿病28 例,其中男 15 例、女 13 例;年龄 48~52(50±2)岁;单纯高血压病组29例,其中男16例、女13例;年龄39~59
(45±8)岁;结合病史、临床表现、心电图、超声心动图,排除肾脏疾病及其他心脏疾患。正常对照组30 例,男 18 例,女 12 例,年龄 40~58(48±9)岁。
1.2 方法 采用GE Vivid 7彩色超声诊断仪,M3S探头,探头频率 1.7~3.4MHz。所有受检者取左侧卧位,嘱平静呼吸。连接肢体导联心电图,记录并存储左室心尖位四腔图、二腔图及左室长轴二维图像,帧频40~90帧/s。将图像传输到EchoPAC工作站,进行脱机分析。在心尖位的三个切面上,按基底段、中间段、心尖段将左室前、侧、下、后壁等及前室间隔、后室间隔采用分析软件分为18个节段。手工勾画出心内膜边界,调整取样区厚度,使其与心肌厚度一致,获取各个节段的应变曲线,测量其收缩期纵向峰值应变。 1.3 临床观测指标 二维超声心动图测量各组左心房(LA)、左心室(LV)大小,室间隔(IVS)及左室后壁(LVPW)心肌厚度,左室射血分数(EF)及左室心肌质量指数(LVMI);记录各组收缩压(SBP)及舒张期(DBP);测量各组间18节段心尖位二维纵向收缩期峰值应变。
1.4 统计学处理 数据采用SPSS 11.5软件处理,计量资料以 ±s表示,采用单因素方差分析,P<0.05 为差异具有统计学意义。
2 结果
2.1 各组二维超声心动图所测指标比较 合并组LVD、LAD 较正常组大,SBP、DBP较正常组高,差异显著(P<0.05);与单纯组比较,无显著差异(P>0.05);IVS、LVPW较正常组、单纯组均厚,LVMI较两组均高,差异均有统计学意义(P<0.05);EF各组间无明显差异。见表1。
2.2 合并组与其他组纵向收缩期峰值应变比较 合并组与单纯组较正常组纵向收