Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein

Modulation of the MAP kinase signaling cascade

by Raf kinase inhibitory protein

Nicholas TRAKUL;Marsha R. ROSNER

【期刊名称】《细胞研究（英文版）》 【年(卷),期】2005(015)001

【摘要】Proteins like Raf kinase inhibitory protein (RKIP) that serve as modulators of signaling pathways, either by promoting or inhibiting the formation of productive signaling complexes through protein-protein interactions, have been demonstrated to play an increasingly important role in a number of cell types and organisms. These proteins have been implicated in development as well as the progression of cancer. RKIP is a particularly interesting regulator, as it is a highly conserved, ubiquitously expressed protein that has been shown to play a role in growth and differentiation in a number of organisms and can regulate multiple signaling pathways. RKIP is also the first MAP kinase signaling modulator to be identified as playing a role in cancer metastasis, and identification of the mechanism by which it regulates Raf-1 activation provides new targets for therapeutic intervention. 【总页数】5页(19-23)

【关键词】MAPK;RKIP;Raf;PKC

【作者】Nicholas TRAKUL;Marsha R. ROSNER

【作者单位】Ben May Institute for Cancer Research, University of

Chicago, 5841 S. Maryland Avenue., Chicago, IL 60637, USA;Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Avenue., Chicago, IL 60637, USA 【正文语种】中文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_cell-research-english_thesis/0201255253376.html 【相关文献】

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