伴JAK2 V617F突变的慢性粒细胞白血病一例并文献复习
Li Zhangkun;Lai Yingchang;Yao Shuyi;Li Xuejing;Zhai Zhenmin;Jiang YirongXia Bing
【期刊名称】《白血病·淋巴瘤》 【年(卷),期】2019(000)005
【摘要】目的 探讨伴有JAK2 V617F基因突变的慢性粒细胞白血病(CML)患者的临床特点、发病机制、治疗及预后.方法 对东莞市人民医院新诊断的1例伴有JAK2 V617F突变的CML患者的临床特征以及予酪氨酸激酶抑制剂(TKI)治疗后的疗效进行观察,并进行相关文献复习.结果 患者发病时巨脾,白细胞计数(WBC)显著增多,伴有JAK2 V617F突变,但临床分期仍处于慢性期. TKI靶向治疗期间,WBC降至正常,但贫血并未获得显著改善,脾脏虽有缩小,但难以恢复正常.结论 当CML患者经TKI 单药靶向治疗而疗效不佳时,不应单纯考虑疾病进展,而应考虑是否伴随有JAK2 V617F基因突变,并进一步探讨以TKI为基础的联合方案的疗效.
【总页数】3页(299-301)
【关键词】白血病,髓样,慢性; JAK2 V617F; BCRˉABL;伊马替尼
【作者】Li Zhangkun;Lai Yingchang;Yao Shuyi;Li Xuejing;Zhai Zhenmin;Jiang YirongXia Bing
【作者单位】Department of Hematology, Dongguan People's Hospital, Dongguan 523059, ChinaDepartment of Hematology, Tianjin Medical University Cancer Institute&Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Medical Research Center for Cancer, Tianjin 300060,
China;Department of Hematology, Dongguan People's Hospital, Dongguan 523059, ChinaDepartment of Hematology, Tianjin Medical University Cancer Institute&Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Medical Research Center for Cancer, Tianjin 300060, China;Department of Hematology, Dongguan People's Hospital, Dongguan 523059, ChinaDepartment of Hematology, Tianjin Medical University Cancer Institute&Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Medical Research Center for Cancer, Tianjin 300060, China;Department of Hematology, Dongguan People's Hospital, Dongguan 523059, ChinaDepartment of Hematology, Tianjin Medical University Cancer Institute&Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Medical Research Center for Cancer, Tianjin 300060, China;Department of Hematology, Dongguan People's Hospital, Dongguan 523059, ChinaDepartment of Hematology, Tianjin Medical University Cancer Institute&Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Medical Research Center for Cancer, Tianjin 300060, China;Department of Hematology, Dongguan People's Hospital, Dongguan 523059, ChinaDepartment of Hematology, Tianjin Medical
University Cancer Institute&Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Medical Research Center for Cancer, Tianjin 300060, China 【正文语种】中文 【中图分类】 【相关文献】
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伴JAK2 V617F突变的慢性粒细胞白血病一例并文献复习
