妊娠晚期B族链球菌感染对妊娠结局的影响及耐药性分析
杜文渊;邹余粮;李彩霞;于晓霞
【期刊名称】《中国计划生育和妇产科》 【年(卷),期】2019(011)003
【摘要】Objective To explore the prevalence of group B streptococcus ( GBS) in the reproductive tract of women in late pregnancy. To investigate the effect of GBS infection on pregnancy outcomes,and to analyze the drug resistance of GBS. Methods From March 2016 to June 2017, 3 674 pregnant women who delivered in 3201 Hospital Affiliated of Xi'an Jiaotong University Medicine Center were selected to perform vaginal secretion GBS bacterial culture at the time of admission. The GBS-positive pregnant women were set as the observation group and the GBS-negative pregnant women were set as the control group. The pregnancy outcomes of the two groups were compared and the GBS resistance was analyzed. Results The rate of GBS infection in the reproductive tract of women in late pregnancy was 1.71 % . There was no significant difference in the rates of preterm delivery and neonatal asphyxia between the observation group and the control group ( P >0.05). The premature rupture rate (36.5 % ), puer infection rate (7.9 % ), and neonatal infection rate (6.3 % ) were higher in the observation group than those in the control group (15.6 % , 0.3 % , 1.3 % ). The differences were statistically significant (P<0.05). Drug
susceptibility tests for isolated and cultured GBS: sensitivity to penicillin, cephalosporin, meropenem, linezolid, vancomycin were 100 % ; amoxicillin sensitivity was 98.4 % ; the sensitivity rates to erythromycin, levofloxacin, clindamycin and azithromycin were 11.1 % , 39.7 % , 14.8 % and 12.5 % . Conclusions GBS infection in the reproductive tract of women during the third trimester increases the incidence of adverse pregnancy outcomes. GBS screening may be routinely performed in late pregnancy. GBS is sensitive to penicillin and cephalosporins, and has a high resistance rate to macrolides and quinolones. Penicillin and cephalosporin should be preferred for GBS infection.%目的 了解妊娠晚期妇女生殖道B族链球菌(group B streptococcus,GBS)感染率,探讨GBS感染对妊娠结局的影响;对分离培养出的GBS行耐药性分析.方法 选择2016年3月至2017年6月在西安交通大学医学部附属三二〇一医院分娩的3 674例孕妇,于入院时行阴道分泌物GBS培养.将GBS阳性孕妇63例设为观察组,阴性孕妇3 611例设为对照组,比较两组妊娠结局;分析GBS耐药性.结果 妊娠晚期妇女生殖道GBS感染率为1.71 % .两组早产、新生儿窒息率比较,差异无统计学意义(P>0.05);观察组胎膜早破率(36.5 % )、产褥感染率(7.9 % )、新生儿感染率(6.3 % )高于对照组(15.6 % 、0.3 % 、1.3 % ),差异均有统计学意义(P<0.05).对分离培养出的GBS行药敏试验:对青霉素、头孢菌素、美洛培南、利奈唑胺、万古霉素敏感率100 % ;阿莫西林敏感率98.4 % ;红霉素、左氧氟沙星、克林霉素、阿奇霉素敏感率分别为11.1 % 、39.7 % 、14.8 % 、12.5 % .结论 妊娠晚期妇女生殖道GBS感染增加不良妊娠结局发生率,妊娠晚期可常规行GBS
筛查. GBS对青霉素及头孢菌素敏感,对大环内酯类及喹诺酮类药物耐药率高,GBS感染应首选青霉素及头孢菌素. 【总页数】4页(64-67)
【关键词】B族链球菌;妊娠晚期;妊娠结局;感染率;耐药率 【作者】杜文渊;邹余粮;李彩霞;于晓霞
【作者单位】723000 陕西 汉中,西安交通大学医学部附属三二〇一医院产科;710061 陕西 西安,西安交通大学第一附属医院妇产科;723000 陕西 汉中,西安交通大学医学部附属三二〇一医院产科;723000 陕西 汉中,西安交通大学医学部附属三二〇一医院产科 【正文语种】中文 【中图分类】R711.31 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-family-planning-gynecotokology_thesis/0201270378370.html 【相关文献】
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妊娠晚期B族链球菌感染对妊娠结局的影响及耐药性分析
