A measure of semantic similarity between gene ontology terms based on semantic pathway covering

A measure of semantic similarity between gene ontology terms based on semantic pathway

covering

LI Rong ; CAO Shunliang; LI Yuanyuan; TAN Hao; ZHU Yangyong; ZHONG Yang ; LI Yixue

【期刊名称】《《自然科学进展（英文版）》》 【年(卷),期】2006(016)007

【摘要】Semantic similarity between Gene Ontology (GO) terms is critical in resolving semantic heterogeneousness when integrating heterogeneous biological databases. Traditionally, distance based and information content based measures are two major methods.In this paper, a new method based on semantic pathway covering is proposed and an algorithm, COMBINE algorithm, is presented,which considers information contents of two given nodes and those of all nodes included in the two nodes' pathways. Experiments show that COMBINE algorithm obtains the highest correlation index compared with those distance based and information content based algorithms. 【总页数】6页(721-726)

【关键词】Gene Ontology; semantic similarity measure; information content

【作者】LI Rong ; CAO Shunliang; LI Yuanyuan; TAN Hao; ZHU Yangyong; ZHONG Yang ; LI Yixue