Combination therapy of long-term tumor treating fields with temozolomide and bevacizumab p

Combination therapy of long-term tumor treating

fields with temozolomide and bevacizumab prolongs survival in multifocal glioblastoma

diagnosed patient: a case report

Damir Nizamutdinov[1,3];Kaiyang Feng[1];Amanda Johnson[4];Ekokobe Fonkem[1,2];;;

【期刊名称】《转化神经科学电子杂志（英文）》 【年(卷),期】2019(004)001

【摘要】The multifocal glioblastomas (GBM) are tumors with multiple discrete areas of contrast enhancing tumors which have considerably poorer prognosis than solitary GBM. Median overall survival of diagnosed patients almost twice as less than solitary presentation. We present a case report of multifocal GBM. A 72-year old right-handed male was evaluated at the Neuro-Oncology Clinic of Baylor Scott and White Hospital (Central Division). Patient presented at this hospital because of persistent progressive headaches, confusion, and an incident of fall. Physical evaluation revealed neurological impairments. Brain magnetic resonance imaging (MRI) revealed heterogeneous contrast enhancing lesions with associated vasogenic oedema. Patient underwent a stereotactic biopsy analysis of the larger lesion and pathology evaluation concluded an isocitrate dehydrogenase 1 and 2 wild type GBM with unmethylated O-6-methylguanine- DNA methyltransferase. Treatment remedies: Patient received 4 weeks