上海出入境检验检疫局REACH和GHS制度宣贯暨培训班-培训资料-GHS部分
第十一部分 毒理学资料
急性毒性：LD503306mg/kg(大鼠经口)；48mg/kg（小鼠经皮）LC50 31900 mg/m3,7小时（大鼠吸入）
急性中毒：轻者有头痛、头晕、恶心、呕吐、轻度兴奋、步态蹒跚等酒醉状态；严重者发生昏迷、抽搐、血压下降，以致呼吸和循环衰竭而死亡。
慢性中毒：主要表现有神经衰弱综合征；造成系统改变：白细胞、血小板减少，重者出现再生障碍性贫血；少数病例在慢性中毒后可发生白血病（以急性粒细胞性为多见）。皮肤损害有脱脂、干燥、皲裂、皮炎。
致畸性：大鼠吸收最低中毒浓度（TCL0）150ppm 24小时（孕7~14天，）引起植入后死亡率增加和骨髓肌肉异常。
致癌性：国际癌症研究中心（IARC）已确认为致癌物。
第十二部分 生态学资料
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第十三部分 废弃处置
废弃物性质：危险废物
废弃处置方法：用控制焚烧法处理
第十四部分 运输信息
危险货物编号：32050 UN编号：1114 包装标志：易燃 包装类别：II
包装方法: 小开口钢桶;螺纹口玻璃瓶、塑料瓶或金属桶（罐）外普通木箱。 运输注意事项：夏季应早晚运输，防止日光曝晒。运输按规定路线行使。
第十五部分 法规信息
危险化学品安全管理条例（2002年1月26日国务院发布），针对化学危险品的安全生产、使用、储存、运输、装卸等方面均作了相应规定。 《常用危险化学品的分类及标志》（GB13690-92），将其划为第3.2类中闪点易燃液体。
第十六部分 其他信息
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填表时间：×××年××月××日 填表部门：××× 数据审核单位：××× 修改说明：×××
上海局工原中心危险品鉴定及包装检测室 技术咨询电话 62505043转蒋伟、陈相和王海婷 第11页 共 23 页
上海出入境检验检疫局REACH和GHS制度宣贯暨培训班-培训资料-GHS部分
Material Safety Data Sheet ( Sample )
Benzene Section 1 - Product and Company Identification MSDS Name: Benzene Synonyms: ××××××
Company Identification: ×××××× For information, call: ×××××× Emergency Number: ××××××
For CHEMTREC assistance, call: ×××××× Section 2 - Composition, Information on Ingredients CAS# 71-43-2 Chemical Name Benzene Percent > 99 EINECS/ELINCS 200-753-7 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: clear colorless liquid. Flash Point: -11 deg C.
Danger! Extremely flammable liquid and vapor. Vapor may cause flash fire. Harmful if swallowed, inhaled, or absorbed through the skin. Causes eye, skin, and respiratory tract irritation. Contains benzene. Benzene can cause cancer. Aspiration hazard if swallowed. Can enter lungs and cause damage. May cause blood abnormalities. May cause central nervous system effects.
Target Organs: Blood, central nervous system, respiratory system, eyes, bone marrow, immune system, skin.
Potential Health Effects Eye: Causes eye irritation.
Skin: Causes skin irritation. Harmful if absorbed through the skin. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis.
Ingestion: May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause effects similar to those for inhalation exposure. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Inhalation: Causes respiratory tract irritation. May cause drowsiness, unconsciousness, and central nervous system depression. Exposure may lead to irreversible bone marrow injury. Exposure may lead to aplastic anemia. Potential symptoms of overexposure by inhalation are dizziness, headache, vomiting, visual disturbances, staggering gait, hilarity, fatigue, and other symptoms of CNS depression. Section 4 - First Aid Measures Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid.
Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get
上海局工原中心危险品鉴定及包装检测室 技术咨询电话 62505043转蒋伟、陈相和王海婷 第12页 共 23 页
上海出入境检验检疫局REACH和GHS制度宣贯暨培训班-培训资料-GHS部分
medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion: Potential for aspiration if swallowed. Get medical aid immediately. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If vomiting occurs naturally, have victim lean forward.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, and full protective gear. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid and vapor. Vapor may cause flash fire. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. This liquid floats on water and may travel to a source of ignition and spread fire. May accumulate static electricity. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Provide ventilation. Approach spill from upwind. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Take precautionary measures against static discharges. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame. Avoid breathing vapor.
Storage: Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Personal Protective Equipment Eyes: Wear chemical splash goggles.
上海局工原中心危险品鉴定及包装检测室 技术咨询电话 62505043转蒋伟、陈相和王海婷 第13页 共 23 页
上海出入境检验检疫局REACH和GHS制度宣贯暨培训班-培训资料-GHS部分
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure. Section 9 - Physical and Chemical Properties Physical State: Liquid
Appearance: clear colorless
Odor: sweetish odor - aromatic odor Vapor Pressure: 75 mm Hg at 20 ℃ Vapor Density: 2.8 (air=1)
Evaporation Rate: Not available. Boiling Point: 80.1 ℃
Freezing/Melting Point:5.5 ℃
Decomposition Temperature: Not available. Solubility: 0.180 g/100 ml at 25 ℃
Specific Gravity/Density:0.8765 at 20 ℃ Molecular Formula:C6H6 Molecular Weight:78.11 Section 10 - Stability and Reactivity Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Ignition sources, excess heat, confined spaces. Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information RTECS#: CAS# :
LD50/LC50: Section 12 - Ecological Information No information available.
上海局工原中心危险品鉴定及包装检测室 技术咨询电话 62505043转蒋伟、陈相和王海婷 第14页 共 23 页
上海出入境检验检疫局REACH和GHS制度宣贯暨培训班-培训资料-GHS部分 Section 13 - Disposal Considerations Section 14 - Transport Information Shipping Name: Hazard Class: UN Number: Packing Group: IMO BENZENE 3 UN1114 II IATA Benzene 3 UN1114 II Section 15 - Regulatory Information European/International Regulations
European Labeling in Accordance with EC Directives Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 36/38 Irritating to eyes and skin. R 45 May cause cancer.
R 46 May cause heritable genetic damage.
R 48/23/24/25 Toxic : danger of serious damage to health by
prolonged exposure through inhalation, contact with skin and if swallowed. R 65 Harmful: may cause lung damage if swallowed. Safety Phrases:
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.
Section 16 - Additional Information MSDS Creation Date: ×××××× Revision # Date: ××××××
上海局工原中心危险品鉴定及包装检测室 技术咨询电话 62505043转蒋伟、陈相和王海婷 第15页 共 23 页
化学品分类及标记GHS概要
