Comparison of Efficacy and Safety between First- and Second-Generation Drug-Eluting Stents

Comparison of Efficacy and Safety between First- and Second-Generation Drug-Eluting Stents in

Patients with Acute Coronary Syndrome

Yuan-Liang Ma;Ru Liu;Xue-Yan Zhao;Jue Chen;Zhan Gao;Shu-Bin Qiao;Yue-Jin Yang;Run-Lin Gao;Bo Xu;Jin-Qing Yuan;Xiao-Fang Tang;Yi Yao;Na Xu;Ying Song;Ping Jiang;Jing-Jing Xu;Huan-Huan Wang;Lin Jiang

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2018(131)012

【摘要】Background: It remains undetermined whether second-generation drug-eluting stents (G2-DESs) outperform first-generation DESs (G1 -DESs) in patients with acute coronary syndrome (ACS). We aimed to compare the efficacy and safety of G1 -DES and G2-DES in ACS patients in a high-volume cardiovascular center. Methods: In 2013,10,724 consecutive patients underwent percutaneous coronary intervention in our institution. We included 4037 patients with ACS who underwent exclusively G1-DES or G2-DES implantation (n = 364 and n = 3673,respectively). We used propensity score matching to minimize the imbalance between the G1-DES and G2-DES groups and followed patients for 2 years. The efficacy endpoints were major adverse cardiac events (MACEs) and its components including target vessel-related myocardial infarction (TV-MI), target vessel revascularization/target lesion revascularization (TVR/TLR), and cardiac death. The safety