皮肌炎血清CXCL10水平与疾病活动度的相关性
张亚妹;彭清林;卢昕;杨阚波;李珊珊;尹利国;王国春
【期刊名称】《中华风湿病学杂志》 【年(卷),期】2016(020)011
【摘要】Objective To investigate serum levels of CXCL10 in Chinese patients with dermatomyositis (DM),and illuminate its clinical significance.Methods Serum CXCL10 levels of 61 DM patients and 32 matched healthy controls were measured by enzyme linked immunosorbent assay (ELISA).The score of disease activity was measured by the same doctor under the direction of MDAAT.And its correlation with serum levels of CXCL10 was analyzed.The results of two groups were compared using unpaired Mann-Whitney U test and the relevance was analyzed using Spearman correlation analysis.Results Serum levels of CXCL10 in DM patients were significantly higher than healthy controls [1 002.65 (446.80,1679.42) pg/ml vs 85.85 (65.88,111.05) pg/ml;Z=-6.886,P=0.000].Patients with ILD had higher serum CXCL10 levels than the patients without ILD (Z=-2.975,P=0.003).A cross-sectional assessment revealed that serum CXCL10 levels were positively correlated with global disease activity (r=0.614,P=0.000),muscle activity (r=0.45,P=0.000),skin activity (r=0.439,P=0.000),and lung activity (r=0.373,P=0.004).Conclusion Serum CXCL10 levels are increased in DM and positively correlate with disease activity.The levels of serum CXCL10
皮肌炎血清CXCL10水平与疾病活动度的相关性
