多西他赛与顺铂同步放化疗治疗局部晚期鼻咽癌的疗效观
察
艾茹玉;周娟;谢波
【期刊名称】《临床肿瘤学杂志》 【年(卷),期】2017(022)002
【摘要】Objective To compare the efficacy and toxicity between docetaxel (TXT) and cisplatin (DDP) in concurrent chemoradiotherapy of locally advanced nasopharyngeal carcinoma. Methods In this study, 72 patients with locally advanced nasopha-ryngeal carcinoma from March 2015 to June 2016 were enrolled. According to the treatment regimes, 27 patients received TXT ( 75 mg/m2 ) on day 1 with 21 days as a cycle and 45 patients received DDP 40 mg/m2 on day 1 every 7 days or 80 mg/m2 on day 1 with 21 days as a cycle. Three dimensional conformal radiotherapy with total dose of 70 Gy/35 f was used for radiotherapy. Response to chemo-radiotherapy was assessed by RECIST criteria 1. 1 at 3 months after treatment and toxicity was evaluated according to Common Termi-nology Criteria for Adverse Events ( CTCAE) v4. 0 and RTOG/EORTC acute radiation morbidity scoring criteria. Results Except one patient in DDP group, the remaing patients were evaluated for the short-term efficacy. The complete remission rates of primary focus were 66. 7% and 81. 8% in TXT and DDP group. The complete remission rates of lymph gland were 81. 5% and 95. 5% in TXT and DDP group. There
多西他赛与顺铂同步放化疗治疗局部晚期鼻咽癌的疗效观察
