血清纤维蛋白原样蛋白1与慢性乙型肝炎肝纤维化程度的
相关性
陈美娟;黄海军;戴伊宁;张家杰;宋文渊;潘红英
【期刊名称】《国际流行病学传染病学杂志》 【年(卷),期】2019(046)001
【摘要】Objective To evaluate the plasma fibrinogen-like protein 1 (FLP1) level in chronic hepatitis B (CHB) patients with different fibrotic stages,and explore the value of FLP1 in the diagnosis of liver fibrosis.Methods CHB patients who underwent liver biopsy (14 subjects each in mild liver fibrosis,moderate fibrosis and severe fibrosis) in Zhejiang Provincial People's Hospital from June 2016 to January 2017,along with 14 healthy controls were collected.The clinical features,liver functions,blood routine and plasma FLP1 level were compared.The independent predictive factors of significant fibrosis (moderate fibrosis + severe fibrosis,S≥2) in CHB patients were analyzed.Results The difference of plasma FLP1 levels in healthy people and CHB patients with different fibrotic stages had statistical significance (F=7.002,P＜0.01).The FLP1 levels in mild fibrosis [(73.2±17.8) ng/mL],moderate fibrosis [(60.5±19.4) ng/mL] and severe fibrosis [(63.1±17.2) ng/mL] patients were significantly lower than that in healthy controls (t=2.267,P＜0.05;t=3.513,P＜0.01;t=3.411,P＜0.01).Older
(OR=1.303,95％CI:1.113-1.526),higher alanine
血清纤维蛋白原样蛋白1与慢性乙型肝炎肝纤维化程度的相关性
