Comparison and Evaluation of Three Animal Models for Studying the Pathogenicity of Staphyl

Comparison and Evaluation of Three Animal Models for Studying the Pathogenicity of

Staphylococcus epidermidis

李华林;王勇翔;陈喆;齐玲;瞿涤;闻玉梅

【期刊名称】《中华微生物学和免疫学：英文版》 【年(卷),期】2003(001)001

【摘要】In order to compare and evaluate three animal models for studying the pathogenicity of Staphylococcus epidermidis strains, three experimental animal models, namely, murine intra-venous LD50, mouse foreign body infection and rat central venous catheter (CVC) infection models were used to assess the relative virulence of two S. epidermidis strains, ATCC 12228 and 97-337. The results from three animal models were comparable, indicating S. epidermidis 97-337 was more virulent than strain ATCC 12228. The rat CVC infection model best mimicked the conditions of clinical patients with intmvenonscatheters, and more information could be obtained from this model. We conclude that different in vivo models serve for dif-ferent purposes, and the rat CVC infection model is most suitable for studying specific characteristics of catheter related infections caused by S. epidermidis stratus. 【总页数】5页(48-52)

【关键词】表皮葡萄球菌;致病性;动物模型;CVC;流行病 【作者】李华林;王勇翔;陈喆;齐玲;瞿涤;闻玉梅