Toll样受体4基因多态性与2型糖尿病并发肺结核患者发
生糖尿病性下肢血管病变的关系研究
李雨泽;侯绍英;陈向丽;张洁;褚光炎;刘玉琴;姜辉;李殿忠
【期刊名称】《中国防痨杂志》 【年(卷),期】2017(039)012
【摘要】Objective To investigate the relationship between TLR4 gene polymorphism and LEAD in patients with T2DM-PTB.Methods We recruited 87 cases with T2DM-PTB patients complicated with LEAD and 68 cases with T2DM-PTB from Infectious Hospital of Heilongjiang Province between September 2013 and June 2015.The basic information of both T2DM-PTB patients complicated with LEAD and T2DM-PTB patients were collected.Meanwhile,peripheral blood was collected in order to undergo gene polymorphism analysis.DNA was extracted by genomic DNA extraction kits and genotyping was accomplished by using Real-time PCR (Taqman probe method).Three TLR4 gene loci (rs 7873784,rs1927911,rs1927914) were tested.Results Allele distribution of TLR4 gene SNPs locus in the observation group and the control group:The G allele of rs7873784 were 91.38％ (159/174) and 91.18％ (124/136) in the two groups,and the C allele were 8.62％ (15/174) and 8.82％ (12/136) in the two groups,respectively.There was no significant difference between the two groups (x2=0.00,P =0.950);The T allele of rs1927911 in two groups were 59.20％ (103/174) and 61.76％
Toll样受体4基因多态性与2型糖尿病并发肺结核患者发生糖尿病性下肢
