Product Data?SheetFumonisin B1Cat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:HY-N6719116355-83-0C??H??NO??721.83AcyltransferaseMetabolic Enzyme/ProteasePure formIn solvent-20°C-80°C-20°C3 years6 months1 monthInhibitors?Agonists?Screening Libraries溶解性数据体外实验Methanol : 10 mg/mL (13.85 mM; Need ultrasonic and warming)Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM1.3854 mL0.2771 mL0.1385 mL6.9268 mL1.3854 mL0.6927 mL13.8537 mL2.7707 mL1.3854 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。体内实验请根据您的实验动物和给药?式选择适当的溶解?案。以下溶解?案都请先按照 In Vitro ?式配制澄清的储备液，再依次添加助溶剂： 为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的?作液，建议您现?现配，当天使?； 以下溶剂前显?的百分?是指该溶剂在您配制终溶液中的体积占?；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的?式助溶1. 请依序添加每种溶剂：?PBSSolubility: 18.5 mg/mL (25.63 mM); Clear solution; Need ultrasonic and warmingBIOLOGICAL ACTIVITY?物活性Fumonisin B1 是?种由 Fusarium moniliforme 产?的霉菌毒素。Fumonisin B1 是 sphingosine N-acyltransferase (ceramide synthase) 的有效抑制剂，破坏鞘脂从头?物合成。 Fumonisin B1 是最丰富和有毒的伏马菌素[1][2]。IC?? & TargetSphingosine N-acyltransferase[2]Page 1 of 2 www.MedChemExpress.cn
体外研究
Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[3].
Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[3].
REFERENCES
[1].?Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7.[2].?Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34(5):527-34.
[3].?Wang SK, et al. Effect of fumonisin B? on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7(6):1970-6.
McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.
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伏马菌素B1作用机制- Medchemexpress- MCE中国
