A PC基因的DNA甲基化与卵巢癌关系荟萃分析
闫冰冰;李力
【期刊名称】《国际妇产科学杂志》 【年(卷),期】2016(043)002
【摘要】Objective:To investigate the role of A PC gene inactivation in the occurrence and development of ovarian cancer. Methods:Databases such as PubMed, EMBase, Web of Science, and CNKI data were searched. Related literatures were published from January 1, 2000 to December 31, 2014. Only randomized controlled trials were included. The quality of the included studies were assessed by Newcastle-Ottawa Scale(NOS). Stata 11.0 software was used for statistical analysis such as OR value,heterogeneity and publication bias. Results:Nine studies, with 641 ovarian cancer patients and 377 controls were included in the Meta-analysis. Statistical results shows that the pooled odds ratio was 6.19 (95%CI:4.08-9.41, P=0.000) in the case group versus the control group under fix effects model. The pooled odds ratio was 5.88 (95%CI:3.662-9.450, P=0.000) in the cancer group versus the normal group under fix effects model. The pooled odds ratio was 6.99 (95%CI:3.12-15.64, P=0.000) in the cancer group versus the benign tumor group under fix effects model. Conclusions:This analysis suggests that A PC gene methylation had an association with ovarian cancer.%目的：进一步探讨结肠腺瘤性息肉病基因（APC基因）的失活在卵巢癌的发生、
发展中的作用。方法：搜索PubMed、EMBase、Web of Science及CNKI数据库中2000年1月1日—2014年12月31日有关A PC基因甲基化与卵巢上皮癌相关的文献，纳入研究均为包含病例组及对照组的随机对照试验。纳入文献采用纽卡斯尔-渥太华量表（NOS）评价标准。使用Stata 11.0软件进行OR值、异质性及发表性偏倚的相关的统计学分析。结果：共纳入9篇文献，其中包括641例卵巢癌患者和377例对照者。总病例组与总对照组的A PC基因甲基化发生率差异有统计学意义（OR=6.19，95%CI：4.08~9.41，P=0.000）；卵巢癌组织与正常组织的A PC基因甲基化发生率差异有统计学意义（OR=5.88，95%CI：3.66~9.45，P=0.000）；卵巢癌组织与良性卵巢肿瘤组织的A PC基因甲基化发生率差异有统计学意义（OR=6.99，95%CI：3.12~15.64，P=0.000）。结论：A PC基因甲基化可能与卵巢癌有关。 【总页数】5页(169-173)
【关键词】卵巢肿瘤;基因,APC;DNA甲基化;Meta分析 【作者】闫冰冰;李力
【作者单位】530021 南宁，广西医科大学附属肿瘤医院妇科;530021 南宁，广西医科大学附属肿瘤医院妇科 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_journal-international-obstetrics-gynecology_thesis/0201235609340.html 【相关文献】
1.癌高甲基化1同源盒基因A9基因启动子甲基化在卵巢癌早期诊断中的意义 [J], 段再康; 梁建芳; 郑绘霞; 肖虹; 程彩霞; 李宁; 王宏坤; 赵玉泽 2.微小RNA基因的DNA甲基化在卵巢癌中的研究 [J], 牛蕾蕾; 李华; 尼华 3.DNA甲基化与卵巢癌耐药关系的研究进展 [J], 王艳清; 杨潇; 鲜舒; 张莉; 程艳香
4.DNA甲基化在卵巢癌研究中的进展 [J], 马敏 5.DNA甲基化在卵巢癌中的研究进展 [J], 王文文
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A PC基因的DNA甲基化与卵巢癌关系荟萃分析
