Anti-anaphylactic and anti-inflammatory activities of a bioactive alkaloid from the root b

Anti-anaphylactic and anti-inflammatory activities

of a bioactive alkaloid from the root bark of

Plumeria acutifolia Poir

Sudharani;S

A Vijayalakshmi;V Ravichandiran;Malarkodi Velraj;S Hemalatha;G Jayakumari

【期刊名称】《亚太热带生物医学杂志（英文版）》 【年(卷),期】2011(000)005

【摘要】Objective: To investigate the anti-anaphylactic, anti-inflammatory and membrane stabilizing properties of plumerianine (compound 1) isolated from the root bark of Plumeria acutifolia Poir. Methods: The anti-anaphylactic activity of compound 1 (10, 25 and 50 mg/kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and its anti-inflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs. Results: A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum. The compound 1 also exhibited significant (P<0.01) inhibition of rat paw edema and granuloma tissue formation, including significant protection of RBC against the haemolytic effect of hypotonic solution, an indication of membrane-stabilizing activity. Conclusions: Anti-anaphylactic activity of