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多西他赛联合奥沙利铂治疗晚期食管癌的临床观察

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多西他赛联合奥沙利铂治疗晚期食管癌的临床观察

汪源;张伟亮;张利东;陈育展

【期刊名称】《中国医药指南》 【年(卷),期】2013(000)014

【摘要】 目的观察多西他赛联合奥沙利铂治疗晚期食管癌的临床疗效和不良反应。方法晚期食管癌患者55例,多西他赛75mg/m2与奥沙利铂130mg/m2联合化疗,21d 为1个周期,连用2个周期后评价疗效。结果全组55例可评价疗效,总有效率63.6%(35/55),完全缓解3例5.5%(3/55),部分缓解32例58.2%(32/55),中位生存期为8.9个月(4.1~21个月),中位疾病进展时间5.5个月,中位缓解时间4.4个月(3~7个月)。主要不良反应为骨髓抑制、消化道反应、肝肾功能损害等。结论多西他赛联合奥沙利铂治疗晚期食管癌近期疗效高,安全性较好,患者可耐受,值得临床观察应用。% Objective To evaluate the efficiency and toxicity of combined chemotherapy of Docetaxel and Oxaliplatin in the treatment of advanced esophageal cancer. Methods Fifty five cases were treated with Docetaxel 75mg/m2 and Oxaliplatin 130mg/m2. The cycle was repeated every 21 days. Results The overall response rate was 63.6% (35/55), with CR 5.5% (3/55), PR 58.2% (32/55) . The median survival was 8.9 months (4.1-21 months), the median time to progress was 4.4 months (3-7 months). The major toxicity and side effects were myelosuppression and thrombocytopenia, nausea and vomiting, which were mild to moderate. Conclusion Combined chemotherapy of Docetaxel and Oxaliplatin is

多西他赛联合奥沙利铂治疗晚期食管癌的临床观察

多西他赛联合奥沙利铂治疗晚期食管癌的临床观察汪源;张伟亮;张利东;陈育展【期刊名称】《中国医药指南》【年(卷),期】2013(000)014【摘要】目的观察多西他赛联合奥沙利铂治疗晚期食管癌的临床疗效和不良反应。方法晚期食管癌患者55例,多西他赛75mg/m2与奥沙利铂130mg/m2联合化疗,21d为1个
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